Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth
Summary: Acute myeloid leukemia (AML) is a heterogeneous st1000nm0008 disease caused by different mutations.Previously, we showed that each mutational subtype develops its specific gene regulatory network (GRN) with transcription factors interacting within multiple gene modules, many of which are transcription factor genes themselves.Here, we hypot